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KMID : 0350519920450041433
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Journal of Catholic Medical College
1992 Volume.45 No. 4 p.1433 ~ p.1443
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Expressions of P-Glycoprotein and Glutathione-S-Transferase in Human Transitional Cell Carcinoma of the Bladder
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Abstract
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The effectiveness of many clinically useful anticancer drugs can be severely limited by drug resistance which appears to be intrinsic to some tumors but can also arise during multiple courses of chemotherapy. Acquired resistance to
chemotherapeutic
drugs typically involves several independent mechanisms and can lead to cross-resistance to structurally unrelated drugs that exhibit distinct mechanisms of action.
Expression of P-glycoprotein(PGP) is one of the mechanism of multidrug resistance and is an energy-dependent drug efflux pump encoded by the MDR-1 gene.
Glutathione-S-transferases (GST) can detoxify a wide range of xenobiotics via conjugation with glutathione. Moreover, transferases by virtue of intrinsic peroxidase activity can also protect cells by reducing organic peroxides to less reactive
alcohlos.
In order to determine whether P-glycoprotein and glutahione-S-transferase could be useful markers for clinical drug resistance, and tumor recurrence, we examined P-glycoprotein and glutathione-S-transferase expressions in normal human bladder
tissues
and transitional cell carcinomas of the bladder.
@ES The results were as follows;
@EN 1. The proportion and intensity of P-glycoprotein expression in cancer tissues(2.9*0.5, 2.3*0.5) were increased significantly compared to normal control (0.8*0.2, 1.1*0.3). The proportion and intensity of glutathione-S-transferase π
expression
in
cancer tissues (3.0*0.7, 1.9*0.6) were also increased significantly compared to normal control(0.7*0.2, 0.8*0.3).
2. The proportion and intensity of P-glycoprotein, glutathione-S-transferase expression in stage P1 tumors were not increased compared to stage P0 tumors.
3. The proportion and intensity of P-glycoprotein expression in high grade tumors were increased compared to low grade tumors, but not significant. The proportion and intensity of glutathione-Stransferase expression in high grade tumors were
also
increased compared to low grade tumors, but not significant.
4. The proportion and intensity of P-glycoprotein expression in recurred group(3.2*0.6, 2.6*0.5) were significantly increased compared to non-recurred group(2.6*0.6, 2.1*0.7). The proportion and intensity of glutathione-S-transferase in recurred
group
were also increased compared to normal control, but not significant.
5. The proportion and intensity of P-glycoprotein, glutathione-S-transferase expression in multiple recurred group were not increased compared to single recurred group.
This study demonstrated that the P-glycoprotein and glutathione-S-transferase expressions are useful tumor markers in transitional cell carcinoma of the bladder, and they may be reliable prognostic factors for recurrence.
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